I've never really liked "the size of the hole" argument. This mostly stems from talking to my ER buddies (nurses) who consistently claim that you can't tell the difference in holes from handgun bullets with the naked eye. If you think about it, the difference between 9mm/.380 (.355"), and .38 special and .357 mag (.357"

) is hundredths of an inch and the difference is not perceptible as a hole in your skin; with .45 (.455") being only 1/10th of an inch in diameter larger and -again- indistinguishable from the other calibers listed. Yet, we all know that .357 magnum and 9mm are very different rounds yielding different results as far as stopping power.
I would argue that the size of the hole is the LEAST important thing to consider, and that what happens once inside the body cavity is exponentially more relevant. As a final example I submit .22lr (.223") and 5.56mm (.224") leaving identical holes. Do they produce even remotely similar results? The size of the hole, while not being completely irrelevant, is the least relevant of properties to consider IMO. IF hole size were that important, we'd all be shooting .50 cal...