A few thoughts:
1) Response times
I agree with the post a couple slots above that suggests the response time will be slower than you'd like. We have glass break alarms in addition to the normal door and window sensors and our cat managed to drop a vase off the mantle. Glass break alarm sounded, system texted me that a breach occurred and the security company called me about 15 seconds later. I confirmed no one was home, and then called the police to dispatch someone to the house.
At that time I was in the next town over at the local gun shop - about 10 minutes away. I arrived about 5 minutes before the police - long enough for me to clear the house and be waiting out front when they arrived. The only thing I found was the broken vase, the cat hiding from the alarm and no signs of forced entry.
Now we live in a suburb and a 15 minute response time isn't their best effort, but it is very normal.
We've had one other alarm over the years and the response time then was about 4 minutes - but that was due to a second officer being very close and enrollee to provide assistance to a traffic accident, they had enough coverage so he diverted to our alarm instead. That was an exceptionally fast response time.
Even in an urban area an 8-12 minute response time is pretty normal, and suburban response times will have something closer to a 15-20 minute response time.
Way back in my deputy days we covered a very large county, and if you were patrolling one end of the county and got a call from the other end of the county a 45-60 minute response time was going to be the best you could do if no one else was available.
2) Think about how to minimize the time available to a thief
As noted above any safe can be cracked if the thief has enough time, and your goal should be minimizing the time available.
a) This is where the security system comes in handy - an audible alarm at least notifies that that the police are on the way and that the police are en-route.
b) Depending on your security company, you may be able to speed the response time when you are on vacation by notifying them that no one is going to be home between specific dates.
Some companies also provide streaming video from cameras to not just the company but also to your cell phone (if you've got sufficient coverage) when the alarm is activated. Video showing suspects in the middle of ransacking your house will potentially get an immediate call to the PD concurrent with notifying you.
Those additional options however will generally cost you more money, either up front in equipment or in a higher monthly monitoring fee.
c) Location also helps. For example we live in a "P" shaped loop at the end of a sub division, so the leg of the P is a choke point as is the fact there are only two streets leading into the subdivision exiting on the same street one block apart. A thief not only has to get out of the house but also travel through two choke points and a half mile to get out of the sub division without attracting attention. So far no one has tried to do that in the 8 years the sub division has existed.
d) A thief (or thieves) in the average smash and grab burglary will focus on the living room and the master bedroom as that's where most of the consumer electronics, jewelry and other easy to pawn items will usually be found.
If the alarm is sounding, they will usually not waste time on bathrooms, or kids bedrooms, other than perhaps a quick scan for video games and TVs. That makes a kid's bedroom closet a good place to place a gun safe, particularly if it is a second closet that can be locked. Bathroom closets work well too, particularly a 3/4 bath with no shower and less moisture issues.
Ideally if your gun safe is suitably placed, a smash and grab thief who is pressed for time will never even know you have a gun safe in the house.
3) Risks in the immediate to intermediate future.
Criminals often share information. If a burglar isn't good at cracking a safe or isn't willing to commit a robbery, he may give your address to someone who is.
Consequently, if you've had a burglary and the thief saw your gun safe, you're a target for a future break in specifically targeting the gun safe. Worse, you're also a target for a robbery, not just a burglary, as having someone in the home gives them the option of forcing someone to open the safe. If a criminal is threatening your wife or kid, you're going to comply.
Keep that in mind if you get a knock on the door. In addition to strengthening the door and door frame, you should consider an external camera to see who's at your front door and more importantly around your front door, before you consider opening it.
Also, even if you do not have a concealed carry permit, (local laws permitting) consider conceal carrying in your home for the intermediate future. If someone kicks in your door, a gun in a drawer in the next room or even across the room won't do you much good.
4) Other deterrents
The good news is that those monitoring signs in the front yard actually provide a pretty good deterrent. If you've got criminals cruising suburbia looking for a house that might make an attractive target (no cars in the drive and no cars in the driveways nearby, with a high probability that no one is home) they are going to target a house without a security sign in the yard.
Dogs are both a good deterrent and a good early warning alarm, but not everyone is a dog person. (Cats are mostly useless, plus they trigger false alarms when they break stuff.) Unless you kennel your dog(s) or limit them to certain rooms in the house when you are out, which I think is cruel, and it reduces their effectiveness at deterring a break in, dogs (and most other pets) also preclude using motion sensors so you'll need to rethink some of the security system to offset that (glass break alarms, etc).
Everybody here has probably seen signs that say something like "This house protected by Smith and Wesson". They probably have some deterrent effect in preventing a further robbery.
We keep a neat house but I intentionally leave my body armor, a holster or two, and a box of my self defense ammo clearly marked as "self defense load" where they are readily visible in the master bedroom. I want to send a clear message that the residents are armed in order to deter a follow up robbery if we ever have a burglary.
5) Gun safes and fire protection.
Most gun safes that are sold as fire safes are no where near to being up for the job. They use gypsum and it provides fire protection only until the board starts to crumble, at which point it falls to the bottom between the steel walls and the firearms get charred. The contacts between the inner and outer walls as transfer heat. And the reality is that in a fully involved house fire a 45 or 60 minute heat rating is not where near long enough as the pile of cinders that used to be your house is going to stay hot for hours.
If you truly want fire protection you need to do some very careful research and be prepared to spend serious money.
You might also want to consider building your gun safe into your house, using multiple layers of a wall board (ideally one that will not fall apart in a fire) on top of, around and beneath your safe, and then incorporate it into a door enclosing your gun safe.
Your best bet though is to just make sure you are properly insured against theft and fire and not have to worry about it