Might not be my first choice, but that J-frame is absolutely enough gun for home defense. Just train regularly with it and consider ammo that fits with your wall construction.
That is exactly what I was fixing to say. I prefer revolvers for home defense and since I carry a J frame constantly it's never too far away from me when I'm home.

It is not my bedside gun, that's a 3" M686+, and I have an assortment of other guns available when I'm home, but that M649 would be easy to get to at all times and would do the job in all likelihood.