Another thing I think about is the cartridge itself, talking about age & pressure limits. Take the 38 special, a very old, and low pressure round.
Say I’m loading for a very modern 38 special revolver, or as is often the case, a 357 gun. I don’t mind starting right near the top of the data, may or may not be the +p column. I just don’t feel the need to spend much time at starting charge levels, unless I want true bunny fart loads.
Now jump to the newer, high pressure 327 Federal round, loaded some recently. With that I loaded right at the starting level with Hodgdon Universal. Even that was a fair bit more than top end 32 H&R mag loads.
That starting level was about right for me, plenty in a lighter gun.