There are a ton of factors to consider in this query.
How much is OP planning to shoot? How deep are OP's pockets? Does the OP want a hunter, or a plinker? How traditional minded are we in this endeavor? Is he a reloader? Does he do any competitive shooting?
I enjoy the .45 ACP revolvers quite a bit. They can easily go up to a 260 grain bullet for reloaders, and for boutique hunting and protection ammo. It's very cheap to load for, plentiful brass, bullets, and factory ammo is plentiful and...more affordable. moon clips are very inexpensive, though to me they do require a little bit of extra thought. For example, I've been known to keep a large portion of moon clips for business only, another stack of moon clips for range use, and throw out any moonclip that I have a modicum of a doubt about. They are ridiculously easy to load. I've found that I could plow through an ammo can of loaded moon clips in record time. Like faster than the flat gun boys during an extended range session. It's not a champ for hunting, but it can check that box, especially for some of the lower 48 folks. t It's also fun to have a revolver to gobble up all the loads your buddy's flat gun can't digest. For factory defense loads, there's also much more of a factory ammo selection. Also, the ACP S&Ws are universally liked, and accurate. Not dealing with the controversy of oversized -5 cylinder throats, etc. To have fun with hot controversy, I could dare mention the .45 Super some convert theirs to as well.
.45 Colt is a joy for hand loaders. So big, easy to handle, and very forgiving, hugely versatile, and able to go from the lightest power puff load to the Tier 2 and 3 loads we love to bicker about. Definitely more top end for the hunter. A bit more expensive to get started reloading, but especially for a moderate shooter, 500 brass will last a very, very long time. I like the recoil impulse of the .45 Colt more. It just feels...more...right to me. And I like that the .45 Colt is such an old classic. An "old man's gun" as my Father would say.
If a person really wanted to break the traditional mold, they could get the .45 Colt, get it cut for moonclips and shoot both. Theoretically, the ACP would not be as accurate, but in real world hands, I'm not sure it would be THAT dramatic as an issue of actual use.
The happiest part to me though, is that if you're buying a S&W N frame of any flavor...it's really darn hard to go wrong.