I seriously doubt it. Let me go try -
Umm, in a pinch, it could work. The front of the trigger guard hangs up at the point the front part of the hand grip rests on a 1911. But the cylinder is mostly encased and relatively snuggly. The barrel muzzle is just at the edge of the leather, but covered.
The problem is the retention strap won't go over the knuckle/hammer and reach down to snap. The rear of the grip protrudes above the top leather backing an inch or a bit. But overall it's snug and there, the problem is the strap is too short, other wise it would work.