I think that, at one time or another, I've put every conceivable shape of grip from every conceivable manufacturer on my revolvers. What I've discovered about myself is that I can't tolerate any grips that are wide at the top of the grip frame. In order to be able to shoot comfortably the grips must be as narrow as possible at that point. I have huge hands -- I can easily palm a basketball -- but I don't think hand size alone is the issue. My problem is how I grip the gun. I tend to take a very high grip on my revolvers (the back of the hammer hits the webbing between my thumb and forefinger when I fire DA) and that has the potential of putting pressure on the base of my thumb if the grip is too wide at the top. Thus, anything that widens the grip frame can be pure torture for me after a few rounds.
Certain grips are just awful for me, particularly S & W targets. They are quite wide at the top and, when I shoot with them, with each round fired a piece of solid wood slams into the base of my right thumb. It is as if someone at S & W deliberately designed those grips to cause me pain.
What I've discovered is that I do best with two types of grips. On anything shooting rounds more powerful than .38 Special, I do best with Pachmayr grippers. Yes, they are ugly, but they are NARROW and that's what matters most for me. Also, the rubber on Pachmayrs completely covers the grip frame and that further protects the base of my thumb. I also do well with Magna grips. They totally disappear in my hand but the narrowness of the grip keeps the grip frame from bouncing against the base of my shooting thumb on recoil. I just bought a Model 19 2 1/2". This round butt gun came equipped with original S & W round butt magnas, grips that look positively tiny when compared to the more modern Hogue rubbers. Yet, I can shoot the gun using the magnas without experiencing the slightest discomfort.