From what I have read, the typical .22 LR bore is .2225, only .0015 smaller than the .22 Magnum at .224. USFA and Freedom arms only use the .22 LR bore for all their rimfires and they are much more accurate than Rugers or S&Ws.
Have had at least five Rugers with extra cylinders and all but one, a Single-Six Hunter, shot poorly with the LR cylinder. And the only Single-Six that I have shot with LRs that was accurate was a 70s vintage * marked stainless gun that from what I understand was bored for .22 LR instead of Magnum. All the Rugers shot great with Magnum ammo.
I also have a Model 53 with the extra Rimfire cylinder that is a great shooter with Jet or LRs. But it is also bored .2225 and can use bullets no bigger than .223 for reloading the .22 Jet ammo.
Bob