I opted for the 460 with 8 3/8" bbl, now, I own a LOT of 44mag pistols, and love them! When making the consideration of what I wanted to buy my biggest thing was hunting...and, I like to get as flat a trajectory as I can get because sometimes what I hunt is 20yds away, but it can also be 200yds away! Since I primarily hunt things like deer, black bear, and the occasional mountain lion. I did my research, and as some have mentioned, when the bullet gets there, the damage is very similar, but HOW it gets there clinched it for me! I currently am loading a Hornady 200gr FTX bullet and it is doing 2200fps, at 225yds I can pop 3" clays all day long. That is without a scope. If I shoot farther than that, or if hunting at dusk or dawn, I will have to add a red dot or something since my older eyes aren't seeing things well when the light is low as they used to! Right now, I'm just using it at the range. The lower calibers, 454 and 45LC and if you get the cylinder cut 45ACP is handy, not something I'd shoot a lot of, but I'd rather plink with these than use my 460 brass and bullets. Honestly, with how easy the 460 shoots, I don't know if my original idea of using this with the light rounds will ever actually happen...and yes, it shoots that easy, no worse than a 44mag honestly!
Good luck on your decision! This was mine to go with the 460, but I think it's a win win for you. Just get the longer barrel, it does make it easier to get on target!!!