Despite what people say, and what misleading perfectly posed pictures you may see, something that size carried under a shirt WILL at multiple points of your day produce an awkward bulge under your shirt. Even loose fitting button up shirts. I know some people don't care, but I'm just pointing that out.
If you carry OWB with a loose shirt, you can conceal it. It would be comfortable and accessible. However, once you start moving and going about your daily life, you'll be bending, twisting etc. and the weird shapes will appear. And again, that isn't an issue for everyone, or every place.
My son in law has carried a full size M&P IWB appendix with no printing or bulges, but he says it gets uncomfortable after a while. I would imagine so.