When carrying your firearm, it should be as quickly accessible as possible, while also being safely holstered. The more steps it takes to draw, the longer it'll take. The condition of your carry pistol is your choice to make. However and whatever you decide to carry - TRAIN, TRAIN, TRAIN. Practice your draw as often as you can. You can't do this enough. I carry a striker fired pistol, round in the chamber, with no manual safety. That works for me.
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