The current production CORE models are also 2.0. If we're talking 2.0 to 2.0 CORE, the CORE, besides the optics ready slide, has an adjustable overtravel stop. COREs are also available with ported barrels (Performance Center).
Note that some "regular" M&P 2.0 SKUs also have optics ready slides.
AFAIK, none of the CORE models have manual safeties except the .45.