Yes, within reasonable limits and with proper caution. I don't have experience with S&W .38 topbreaks yet, but I own and have fired Iver Johnson, H&R, and Hopkins&Allen .38 topbreaks from the era, all of which were considered lower quality than S&W, and have had no issues. The problem with guns that old is never the strength of that type or model as such, but what abuse the particular gun has suffered over the past century from previous owners. When I've shot guns like these, I basically take the same precautions as when shooting muzzleloaders, i.e. inspect the gun, especially the cylinder, frequently while shooting and be prepared for the eventuality that something might come flying in other directions than just out of the muzzle. But manufacturers are aware that with an obsolete caliber people are going to be stuffing it into antiques, and keep pressures down accordingly.