My sentimental favorite .22 revolver is an old Colt Official Police with a 6 inch barrel and wood checkered stocks. My grandfather gave it to my mother about 1948 or 49 for protection and she used it to shoot a Peeping Tom when it looked like he might try to come in her bedroom window.
My favorite to shoot is a S&W Model 18 Rimfire Combat Masterpiece, that name which Jeff Cooper pronounced as the "exaggeration of the century." I bought mine in April, 1977, and screamed so loudly at the cost of $162.23 that Mom thought my girlfriend had left me. I did my first attempt at an action tune on it, as described by Skeeter Skelton, and added a smooth, wide "combat" trigger and white outline rear sight blade to it. A pair of Pachmayr Presentation grips and a Bianchi 5BHL holster and the sixgun is ready to defend me from the ravages of waves of attacking ground squirrels, picket pins and pot guts.
I have bigger ones, smaller ones, stainless ones, lighter ones and Magnum Rimfire ones, but the Model 18 is my favorite and I may have fired more rounds from it than from any other handgun I own.