It depends. 5.56 brass is loaded to significently more pressure (NATO pressures are higher than SAMMI) than a .223, that is part of the reason for the long throat (Wheatherby used the same principle to reduce pressure). Some .223 throats are longer or shorter than others, so it kind of depends on the throat in your particular rifle. If you have a good solid bolt action, you are unlikely to have a Kaboom, even with a short throat. Go ahead a try a few rounds. If your bolt is sticky and hard to open, then you know to stay away from 5.56