Colt made a varition of the Frontier Scout that came from the factory with both the .22 LR and .22 Magnum (.22 WMR) cylinders. The Peacemaker .22 and New Frontier .22 revolvers made in the 1970's were all designed to shoot both. There were some other makers as well (H&R, Iver Johnson?, some foreign models).
Several Smith & Wesson models in .22 Magnum caliber (48, 648, 51, 651?) were also available with .22 LR cylinders.
If a .22 LR cartridge is fired in a .22 WMR (Magnum) chamber, the case will very likely split releasing hot gas and brass fragments out the side. Unpleasant at best and injurious at worst.
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