While at Bass Pro Shop yesterday, I was deciding between Bullseye, 2400, and Unique (they have others but I knew nothing of them) but picked 2400 and seems like it was not a very wise choice for my situation. I plan to go back to BPS today and pickup 1lb of either Unique, or Bullseye or W231 (not sure they have this on the shelf). This is an hour drive one way so still debating about going today or not.
2400 is a great powder and not an unwise choice, simply not the most flexible powder given what you want to do. It will work very well in mid-range to full loads in the 357 and in full loads in the 38. It is also better with the lighter bullets than H110/W296. It is probably the most useful 357 magnum powder, giving consistent results over a relatively wide range of pressures and bullet weights.
H110/W296, they are exactly the same and use the same data, are designed to give the highest performance from straight wall cases at magnum pressures. They have a very narrow range of operating pressures (high) and work best with heavy bullets. They are the best powders for full magnum loads but the least useful for anything else.They are proven unsafe for light loads, giving hangfires and squibs when loaded too light or under light bullets.
Red Dot, Bullseye and 231 are all great for the 38 and I have used them all in 38's and midrange 357's with great results. You must watch for double charges with the lightest loads, they don't take up much space in the case. You will be happy with 231 in your 38's.
I load 38/357, 44Spl/44Mag, 45 ACP and 45 Colt, as well as 12 and 20 gauge shotshells, and I cannot imagine reloading without Unique.
I loaded my very first batch of 38's with it in 1980 and have never been without some since. It is the single most useful and easiest to work with powder for all of the calibers you want to load. Forget the complaints about smoke. All powders give some smoke, and flake powders lubricated with graphite give more. Lubricated lead cast bullets are smokier with any powder than plated or jacketed bullets. It's just part of shooting and the only people who complain are those who don't don't like to clean their guns or think shooting real guns should be like a video game.
The flexibility, economy, excellent ballistics and general easy going good nature of Unique far outweigh any perceived smokiness issue.
BTW, all of the powder selection criteria for 38/357 loads apply to any of the straight wall cases. They all work the same, based on case length and pressure. Shorter case, lower pressure, use a faster powder. Longer case, higher pressure, use a slower powder. The 9mm is the slight exception, only due to the combination of short case and high operating pressure. And Unique is fine for the 9.