I used to be a .45ACP 1911 guy, largely influenced from my time in the Army, until I suffered a wrist injury to my dominant arm. Even after surgery and months of rehab, my wrist would "unlock" under recoil of anything larger than a 9mm. I switched to a revolver for my .45ACP, and tried the .40 first in a model 4006, and later a Sigma 40F. I now have arthritis in both hands, and I find the Sigma to be "softer" in recoil than the much heavier 4006. I am comfortable and fond of both calibers, but for me, it depends on whether I'm using a revolver or a semiauto that determines the caliber for me - I also believe that "bigger is better". By the way, a Model 610 is vying for the number one spot on my "grail gun" list.
Best of luck,
Dave