John Linebaugh is something of a guru when it comes to questions like this. He is an extensive tinkerer, and he probably has as thorough a background in it as anyone. He believes that a "practical" big-bore sixgun does all it can do with a heavy, flat-nose, lead bullet in the 1100-1200 FPS range - little is gained beyond that, and sometimes, things are lost. (Possibly here John is considering the ability of most shooters to hold on to that gun as it is launching those big, heavy bullets much faster than 1200 FPS.

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I believe him, but the problem I have with this is developing loads in magnum cases in that range that burn with the consistency that a 30,000+ PSI #2400 load does. The #2400 load is usually more than I want, but I cannot duplicate its excellence at a lower level.
One can mitigate this problem somewhat by switching to a slightly heavier (+10% or so) bullet and by taking care to use good cases with a solid crimp, but if one goes too heavy - say to 300+ grs in the 44 Magnum - sometimes there is a such a divergence in POA-POI that it cannot be corrected with the standard sights on a Model 29. This is where the easily-replaced front sight of the DX-series guns was a boon, but unfortunately for me, it came along after I had worn myself out shooting full-charge 44 Magnums. And of course a 300-gr/1100+ FPS 44 is definitely full-charge, as far as I am concerned. So nothing is gained there. It may be harder on the gun and shooter than the usual 250 at 1300.
Finding a nice, easy-shooting 44 load, particularly in the 1000-1100 FPS range, that burns cleanly, that does not lead, that the chronograph says is consistent from shot to shot, and that is accurate in most guns has been an elusive target, for me, at least. I don't have the same amount of experience with the .41, but I suppose it is the same thing there... ? I have always relied on Unique, but I have never been happy with it, and 231 is no better.