If you're an experienced hand loader, 45 Colt is superior to 44mag in both handgun and rifle.
There's essentially three levels of pressure loads for 45 colt. Standard cowboy loads. 14,000 psi. Even the existing guns made in 1873 will handle these. Modern manufactured handguns made after roughly 1970 will handle all 45 Colt loads that are the equivalent of 45acp+p pressure (24,000 psi) and then the 45colt +p loads that are listed usually as the Ruger/Thompson Encore loads at 31,000 psi. Most/many of the third tier loads will exceed top end 44 mag loads in muzzle energy. Any rifle will handle the Ruger/Thompson Encore loads (i.e. 30,000 psi) with no problem.
So there's tons of versatility in power with 45 colt. It's a larger bullet that cuts a bigger hole and can deliver more power on target in the right platform.
But it's also more complicated to keep track of all those different types of loads for different guns. And you can't really buy any Tier 2 factory ammo. Just tier 1 and tier 3. If you're not a hand loader 44 mag is likely the better option.
Hence the 454 Casull since folks kept trying where Keith came to his senses.
99% of what we do with guns and ammo is for fun and sport.
Theres nothing wrong with this, even if you must assign some flavor of justification to it for others.
You're among friends here, embrace and admit to this 99%. it's okay.
this leaves the remaining 1% where work must be done, often under pressure where one may have time to grab a gun and scoop up a handful of ammo to take care of business.
Let's say you manage a non +P 38 and a handful of 38 you loaded for a 357 mag rifle well past +P when duty called.
This might not end well.
My 38's are loaded for all 38's ... all.
If I want or need more, it's loaded into 357. One size fits all.
in 45-70, this one size fits all principal is satisfied a little differently. there is not, nor will there ever be, any so chambered arm in my collection that is of a standard less than the 1895 lever action benchmark.
This principal is maintained across everything.
Split standards will never cause a bad day to get worse, or a range day to turn bad