As per Mr Keith in an article written in 1968,a 22.0gr 2400 with his bullet from a 7 1/2 SuperBlackhawk drilled all the way to the heart in an elephant(didn't do it himself;he reported it).I thus don't doubt that same bullet at aprox 2/3 it'svelocity,as per Skeeter's load,can and will drill deep enough into a deer.KT bullets are notorious for deep penetration while cutting a good size hole.
I'd use Skeeter's recipe without a second thought if that's what my gun preferred.
Qc