I fell in love with the .45 Colt cartridge some 30+ years ago. Unfortunately, the classic Colt SAA style guns don't get along with me.

However, I dearly love the S&W N-frames in that caliber. I currently have 4 of them plus a Navy Arms/Uberti Schofield.

The classic .45 Colt load is a 250-255 gr lead bullet over 8.0-9.0 grains of Unique. This generally runs in the 800 to 900 fps range. I loaded 8.5 for many years, but due to my age and powder availability have cut back to 8.0 now. There's still plenty of power there for whatever your needs may be.
The Model 25 is stronger than most people think. While I caution against magnumizing the .45 Colt, the Model 25 can handle loads up into the +P range quite well. I have loaded some pretty heavy bullets to 1000 fps without any ill effects.
But then considering that the standard velocity .45 Colt will go completely through the average whitetail deer, I see no reason to push my .45 Colt loads anymore.