I've been shooting various .45 Colt revolvers, rifles, and a carbine for more than forty years, mostly with the Lyman #454424, about 255- 260 grs. I thought I had tried Bullseye at one time, but cannot find it listed in my notes.
That's a huge case for such a fast powder, though it may work fine. However, I'd attempt to locate published data from a reputable source before I would rely on Internet suggestions. Check the Alliant paper manual (or perhaps the website) and the Speer book. Speer often uses powders other manuals neglect. There are likely other sources.
I don't shoot .45 Colt much anymore. I used Unique for many years but found HS-6 to be a slightly better .45 Colt powder. As for elevation adjustment, my two 25-5s, a 4" and 6", always shot high (about 3"-4" at 25 yards with the elevation adjustment all the way down. This was with muzzle velocities of around 800 fps with the 4" and 850 fps with the 6". A higher velocity will correct the problem, but with noticeably increased recoil.
I doubt you'll be able to get 900 fps with a heavy bullet using Bullseye powder and stay within standard pressure parameters, but that's only a guess on my part. People load these guns hot, but I wouldn't do it.