I use .45 Colt in both handguns (Perf. Ctr. Model 25, Colt SAA, Ruger Blackhawk) and rifle (Uberti Model 1973 and a custom made low wall single shot for 200yd. targets).
You MUST look at commercial loading data in a couple of manuals, factor in what advise ou have from the forum and shooting friends and decide on a STARTING load FOR YOUR GUNS. Usually, for rifle loads, I back off commercial hot loads by 10% and work both up and down in 0.1gr increments until I get my best groups from a bench. If accuracy is down, then a few more Ft./Sec. will do you no good. Now, keep in mind that some powders (like 296 and H110, essentially the same powder) will generate excessive pressure if too light! Again, use the manuals carefully.
Here is what I have used successfully for years. I have been reloading for over 50 years…….
.45 Colt … 260gr.PbSWC, Gas checked….over 15.5gr.2400
Works in all my handguns and rifles…. good place to start.