Some years ago, I decided it was time for me to get started in .45 Colt, so I bought a lovely 25-5, dies, bullet moulds, bullets, powders and primers. Got my brass from factory ammo and spent several months punching paper, pine cones and soda cans, and developing loads.
Long story short, I never could make that gun shoot worth beans, plus I had a difficult time with split cases, scraped cases in sizing, and pulled rims after sizing. At that time, I had probably 30 yrs experience in handloading, so knew the importance of case lubes, bullet lubes, pressure signs, etc. and none of it worked.
Ended up selling the entire pkg, everything I had that was to do w/.45 Colt, and haven't had another since. I've satisfied my big-bore cravings w/.44 Special, .44-40, and .45 Auto Rim, all with big smiles.
Not trying to be a wet blanket, just so you know that sometimes, even for a guy with experience, the magic doesn't happen.
Good shooting, hope your experience is better than mine.
Larry