Grit-
It would have to be an X frame. Even if it was put into in an N frame with a 5 hole cylinder, the gun wouldn't last. The recoil would beat an N frame apart in very short order. I own an F/A 83 in this caliber, so I know whereof I speak. It is an awesome round that can be fit into a smaller gun than the huge X frames, but it would have to be bigger than the N frame.
Actually, if S&W would just shorten the X's frame and cylinder for the .475, that would be awesome for sure.