Had my 6.5" 500 mag at the range today and suddenly it got very stiff in SA (almost locked up). DA works fine. Any hints as to what's going on? No extractor screw problems (first thing I checked). But wont index in SA. 
Do you mean the mainspring screw? Revolvers don't have an extractor screw at least that i'm aware. The mainspring screw on the front of the grip frame can cause problems if it loosens up.
Sometimes with the big magnums the fired case gets driven against the recoil shield and binds the action. This is generally a problem when using ammo that gives sticky/difficult extraction. The reason it may be more pronounced in SA over DA may be a leverage thing.