I typically use the discs in my several Lee PRO Auto Disc measures. I definitely suggest to go for the Pro Auto disc instead of the less expensive one. The "off and on" plus thumb screw removal makes things simple to change discs.
However, I DO have an adjustable slide and use it when it is within it's range. It works just fine.
I have a couple of Dillon 550B's as well as several of their powder measures (I also use the Lee Pro Auto Disc on my Dillons, when needed). I only use "measure friendly" powders in all of my progressives and auto measures. There are ball powders in nearly all burning ranges and they are generally my first choice (even in rifle cartridges).
However, a number of flake powders also work well for me (Bullseye, Unique, 5066, etc) and I have no problems using those.
There are definitely powders to stay away from as they tend to hang up in ALL powder measures:
4759 is a very large grained powder intended principally for old black powder cartridges (it is bulky, takes up a lot of space, is porous and ignites easily but is VERY hard to measure - often bridges in measures).
700X is a bad offender for bridging in powder measures (this is a shame as it is a very clean burning powder that shoots well in pistol calibers). After several "incidents" experienced by myself and friends (as well as a couple of commercial loaders of my acquaintance), I have taken this powder OFF my list.
Large grain powders such as 4350 and 4831 don't get run through my progressives, either (I use them with a Lee Classic Turret with a conventional measure and inspect each case as loaded).
But, the solution that works well, for me, is to just emphasize the use of ball powders, other than the flake powders that work well.
Dale53