I have basically settled on one bullet/load for the 500 for all purposes, and did take a deer with it two years back. It was a close shot, roughly 30 yards over the iron sights, and when the gun came down from recoil all I could see of the deer was his four feet sticking straight up in the air. The load is a Cast Performance 440 grain WFNGC, a so-called 'heat-treated solid' although I'm not sure how one heat-treats lead, but oh well. It is a Keith style bullet. I load it with 40 grains of WW296. It isn't a maximum load, but not far short of that, plenty warm. It is not too far removed from the factory Cor-Bon 440 grain lead-bullet loading. It slaps stuff down.