I've owned many revolvers over the years. Some pretty good for their intended purpose and others not quite up to speed. If I was picking one revolver for self defense it would a Mk V Webley. I've never owned any revolver that point shot as naturally as those large frame, birds head griped Webleys PLUS they are a fairly quick reload. Yes they may be slightly less powerful that the 45 ACP, but not enough to matter.