B.C., Peanuts, Dilbert (when I was working at least), The Wizard of Id, Hagar the Horrible. All of these had a few that really slayed me, but none of them have hit home as consistently as Calvin and Hobbes.
When I first saw Calvin and Hobbes, I thought it was stupid. I mean what kid has a tiger for a pet? When I realized that Hobbes was really a stuffed toy, it hit me. This is GREAT!!!!
And even then, the more I read, the more I was taken by it.
The Killer Snow Goons, Spaceman Spiff, G.R.O.S.S. and 'hating' Susie Derkins even though he secretly wants 'smooches' by proxy from Hobbes.
And I agree with Bill Watterson that comics USED TO BE in glorious color, and BIG!
Remember when all the sports fans had a sticker of Calvin peeing on whatever team or driver they hated? I was a Jeff Gordon fan and I had one peeing on #3. My wife was Redskins fan and had one peeing on the Cowboys.