I suggest that you pose that question to Outpost75. He worked in the industry for many years and can give authoritative info. Plus, he has customized many firearms and bullet molds that give him "deep background" on these issues. You can reach him by private message on the Cast Boolit Forum if you have problems reaching him here.
I have some experience with revolvers as I have cast my own bullets since about 1949 and shot competitively many, many years. Some years ago, I obtained my first 686 (a "overrun" of the CS-1 with 4" barrel). I shot it so well out of the box that I started looking for a 6". At the OGCA gun show I found a 6" 686, like new, from an estate sale. It looked like it had hardly been shot. When I took it to the range, it spitted everytime it was fired. I measured the cylinder clearance between the back of the barrel. It was at the S&W limit (about .012", as I remember). Fortunately, we had an excellent local pistolsmith who was a retired policeman who had, for years, been the armorer for the Cincinnati Police Dept. He was factory trained, and had worlds of experience. To add icing on the cake, he was/is not only very talented but also quite reasonable.
He, while I watched, removed the barrel, set it back, rethroated it, and re-installed it to match specs. I now have a revolver with minimum specs, no longer "spits" and shoots like a laser. I could not be more pleased.
FWIW
Dale53