Some gauge (small amount) in these components is actually necessary for proper function. This gauge or "play" in the assembly comes initially from fitting the cylinder stop to the smallest stop slot in the cylinder. Since these slots are not always exactly the same size, there is some play or gauge introduced at that interface.
Also, you have the difference between the width (size) of the stop ball, and the width of the stop window in the frame, which adds a bit more movement. (also necessary)
The key is getting the timing set so the cylinder rests at the correct spot when the gun is fully indexed in terms of barrel/cylinder alignment, and is ready to fire. Using a range rod to verify chamber and barrel alignment can help with this critical fitting.
Wear and tear and abuse can, and do take their toll. Fortunately, there are "oversized" parts available, and other corrective measures, like micro-welding, you can employ to address most of these problems, and bring the revolver back into spec.
As usual, Jerry Kuhnhausen has some very interesting information about these specific parts relationships in his shop manual.
Sorry Pete, but I can't actually answer your question definitively. I think you'll know when it feels out of spec by comparing it to your other S&W revolvers.
Carter