Yes, you can load that 500 to severe recoil levels and it will sting your hand and if you go the non-ported route either custom or the John Ross model your wrist will get a work out as well with the super loads. I would recommend a good pair of shooting gloves and you will be amazed at the difference in "felt" pain levels. Some people can use the PAST gloves without a problem but I've ruined 2 pair real fast with the 500 loaded over the top. I now use Grip Swell gloves and I think they will work for me. I received the gloves yesterday and fired 60 rounds of full house plus rounds and the gloves held up (that's 50 rounds more than the PAST gave me). The Grip Swell is a little "bulkier" than the PAST and the trigger finger is covered but I didn't find that to be a problem. With my single action 50's my 1st knuckle on my trigger finger takes a bloody beating with anything much over 1,300fps, so the covered trigger finger is a plus. I'm thinking about cutting a hole in the bottom of the trigger finger, so I can feel the trigger better but I'll wait awhile to see if I can get use to the "leather" feel before I start cutting on a very expensive glove. It really doesn't matter what magnum handgun you shoot, you'll control it a little better (for some this isn't a big deal) and you'll enjoy shooting the heavy rounds more, as the padding soaks up the "felt" pain and all you soak up is the concussion and body jolt for lack of a better term.