My 1966 circa model 15's yoke retention screw tends to back out. I've put thousands of rounds through that revolver and it's my first gun. For me, locktite on revolver screws is a blessing. YMMV
I fully agree. My Revo's are in the carry rotation and the least carried/shot Revo gets 200-300 rounds thru her a year and the most carried gets at least 1000-1500K her, and usually more. Both my M629 and M625 had the cylinder release screws back out in under 400 rounds and the M625JM exhibited misfires/light strikes with self defense "light primer" strikes with the strain screw within 500 rounds. Both also had sideplate and yoke screws back out under recoil as well. And *Both* are/were at one time my Woods Gun(s) and any (malfunction) is unacceptable in any carry role but especially in a Woods-Gun when I have my girls with me. Both were fully disassembled completely, every screw was de-greased gently with dental tools/pics, and then every screw got (2) dabs of purple loCTite; then every part and finally every screw was re-torqued to two hairs past snug.
I've yet to have one failure in either with "Full-House" Underwood, Buffalo Bore, my loads, or any other factory load thru either of them since the above aforementioned disassembly, cleaning, and reassembly/torquing with 2 dabs of purple LoCTite.
That said, My 70's Manufactured M-36's, 80's Manufactured Colt "Agent", and 85' Manufactured M29 Lew Horton Special have had a bevy of "hot-snot" loads thru them and none have even so much have had a sight, yoke, side-plate, cylinder release, nor strain screw back out to any degree.
Below are both the M625JM and M629 that have exhibited screw back out's in factory/sans thread locking "LoCTite" present. Both are Sunrise Reliable now though.. And both with the "88's" removed as well..