I am left handed, but right eye dominant. I have always shot long guns from the right shoulder, but handguns in the left hand. I have never felt disadvantaged.
With revolvers, I have had no problem with reloads. What works for me is for the right hand thumb to come over to hit the latch, pressing the cylinder out with my left fingers. Right hand comes over the top to slap the ejector rod, and right hand reaches for the speed loader or speed strip. After the rounds are seated the left hand closes the cylinder and the shooting grip is re-established. Easier to do than to describe.
With pistols with external safeties, like the 1911, I require an ambi safety. However, manipulation of mag release is done with my trigger finger. Guns without external safeties, like Glocks, don't require any modifications.
Weak hand (right) drills have been no problem, since I am already used to trigger work on the right side due to long gun use. Although much slower than using two hands, I can reload both pistols and revolvers one handed should the need arise, but you have to get creative, such as using your belt as a support (this often does violate Rule # 2, but if your life is on the line...)
Other than finding it hard to acquire holsters at times, I have not felt disadvantaged being left handed in the least.
