Firstly, for clarity , JoeP1940 is speaking of " Pre Fragmented defensive ammo . Frangible Ammunition in the Military rifle context is something different .
RIP - No
Glaser - Yes , and moreover the Mag Safe .
As a couple have posted above , Pre Fragmented is a very specialized ammo , for specific actual or perceived requirements.
Absolutely, positively, not penetrate interior walls .
Absolutely, positively, not penetrate completely thru the intended bad guy .
With those two controlling parameters , even if significant compromises in other factors.
* Disclaimer- I don't obsess over deep penetration, but there still is a big difference between sort of enough , and way too little *
Yes ! From personal experience, a .38 +P+ will Not penetrate an interior sheet rock wall .( But will leave your ears ringing for hours )
The difference in POI even at less than 7 yards ranges from significant to unbelievably huge . When we say Close Range , we mean it ! 3 inch low at 5 yards , you could live with . 10 inches low , not so much .
My experience was mainly with Revolvers . Because Revolver and Feeding Issues don't fit in the same sentence. But these very light bullet , very high velocity loads has very different recoil impulse , and slide velocities. They might well cycle reliably in your semiauto, but you can't assume that , you need to function test . I just did an internet price check , and prices have surprising come down relative inflation. But still $17/ 10rd , plus shipping is nothing to sneeze at . But not impossible, if you budget $100 for minimal function test and sighting , and one mag to carry .
Development back story ( simplified):
In the beginning was Jack Cannon & Glaser . Used #12 shot . Penetrates 2- 4 inches for the various pellets .
Zoe Zambone tested some Glaser . Liked the concept , but thought the penetration was waaay too shallow . Invented a Better Mouse Trap . Initially used #6 shot , and in subsequent R&D ended up with different size shot in different calibers and loads, Ranging from #6 to #2 .
The subsequent corporate owners of Glasser saw Mag Safe eating away their market share , and had to do something to compete .
The original Glaser line was renamed Gkaser Blue , and the new Glaser Silver with #6 .
Even For Me , +/- 3 inches of penetration is waaay too little .
Current 10mm Mag Safe with 8- 13 inches ? Opinions will rightly vary. If you had actual need to not penetrate an interior wall at close range , it's something to consider .
BUT as I'm interpreting the OP's search for general purpose carry/ defense ammo , I'd recommend against any Pre Fragmented ammo .
If you were to have a predisposition for penetration on the lower end of the general use spectrum , look to the various 150/ 155gr JHP , with 4 layer gel penetration in the 12-14 inch range .