ANY pistol should be ready to go with ONLY ONE HAND available - IMHO! While being attacked, you may not have the luxury of using a second hand! You may need it to defend yourself, to grab on to a support, open or close a door or whatever. Carrying a SA pistol without one in the chamber is just foolish in my opinion.
That said, if you really do not want to carry a SA with a round in the chamber, carry a DA revolver! At least it is ready to rock with one hand at all times. Yes you are sacrificing round capacity but at least it is ready with only one hand available.
I carry a Sig P365 with one in the tube but I do have the model with an external safety (did not originally). At least on the P365, the safety is effective and is easy to flick off and pull the trigger in one fluid motion. I know some dislike the external safety but it is still a one handed operation and adds just another layer of safety. On a striker fired and pocket carried (at least 1/2 the time) Micro pistol it just makes sense to me. IMO it does not slow you down after practice.
PS: I laugh at the guys who use a one handed cocking method by rapidly throwing the gun forward or using their belt to assist in a one handed cocking. Not only is this just another step but it may not actually be feasible. I'd like to see that work from a seated position in a car, tight place such as a crowded elevator, and certainly alerts everyone around you that you have a gun you're getting ready to shoot. Nope - clicking the manual safety to off is about to the extent I will go in the safety dept.
Of course it goes without saying, no matter what type and brand of gun you carry, constant weekly practice (even without live ammo) is the way to stay sharp.