I agree with dan01. I have autopsied many victims of .410 shots. At close range it will put a very serious 1/2 inch hole in you and many times gos all the way through.
medxam
Thanks. That sort of answers the question I asked here some months ago about whether a character in a fan fiction that I was writing could have put a tight enough charge of shot from her 12 ga. Purdey into a charging chimp from about ten feet or less. I wanted the shot to still be clumped and hit like a more or less solid mass. She needed that angry chimp to drop right then. It worked like a charm in print.

Glad to know for sure that it'd do that in real life, too. That chimp was one of a group using primitive hand axes to bash open the skulls of local natives. They thought that the dead were victims of the probably mythical Nandi bear.
I have a single-shot .410 that was my first gun, age 6. I couldn't hunt with it for several years, as it was too long for me and the recoil was more than my dad thought good for a child. When I did begin hunting, I soon found that it was best to take sitting shots, to avoid wounding game. I killed a mallard at some 30 yards on the wing once, but usually shot more cautiously.
I think the .410 is best regarded as a candidate for a survival gun, not a sporting one for hunting. Shoot within reasonable range, "shoot sitting", and eat. This was the concept for the M-6 bailout gun for bomber crews with a .22 Hornet barrel over a .410 barrel and ammo storage in the stock.
I was surprised to read above about that raccoon taking so many .410 slugs! Wow! That was a tough animal. It does show that shot placement is critical.
Today, I won't hunt with less than a 20 ga. and I own a 12. I am afraid to shoot any bird that I can't put down with a three-inch 12 ga., and normally stick to 2.75-inch shells. The old .410 will probably go to a grandson. But I'll warn him not to use it for flying game. Maybe I'd "shoot flying" with an M-1100 in .410, but not with that single-shot. BTW, I think it was made by H&R or Iver Johnson for Diamond Arms Company. That seems to have been a brand sold by Shapleigh Hardware.