The barrel of an M4, M16, etc. is never removed for cleaning, even under harsh combat use, and it is way harder to clean than a 15-22, so I would leave the barrel in. The barrel, barrel nut, and upper receiver are not designed to be repeatedly removed.
You can do what you want, but if you keep taking it apart and putting it back together, eventually I think you are going to find it's going to get sloppy. If you removed and reinstalled the hinge screws out of the front door of your house every 100th time you used the door, eventually they won't stay tight.
Detail clean inside the upper around the chamber with this stuff occasionally. The carbon and fouling just dissolves away and there is absolutely no need to disassemble to use it:
Link