Not trying to shove this on anyone, this is the way that works for me. I've tried in the past to explain it. Its not something easy to explain, so I had my son do a little video of how I do it.
Firearm SW 10-8
Ammunition Georgia Arms 158grSWCHP+P
Yup, that's how the military taught this lefty how to do it. Cylinder open, thumb through frame over cylinder, muzzle up, slap doohickey with left hand ( ok, ejector rod), fill the belly with ammo and proceed with the fun.