I am appalled at the comments expecting a lefty to just conform. It's rather ridiculous that such a simple and justified question has received ignorant answers. We may be less than 20% of the population, but we are different, both physically and mentally than a right handed person. Some act like it's an abomination to want their shooting experience to be more comfortable. We have a hard enough time with some everyday objects, we don't need to be ridiculed for this. In life or death situations, every millisecond could be the difference. So it's fair to not want to switch hands twice when I shouldn't have to to begin with. I also figured that a 166 year old company might have one option for the other hand, even if custom. It's understandable they don't have a production model configured opposite but it's fair to ask. Harping on people is not how you grow the S&W community. Those that found it funny or acceptable to judge should be ashamed. How would you like it if you were forced to do everything backwards?
As for the gun, Smith and Wesson unfortunately do not offer a left handed revolver, but Charter Arms makes one called "Southpaw" which is a .38 special chambered for 5 bullets. This is special because It's there only revolver currently made where the cylinder swings to the right, so the gun never leaves the shooting hand. It's American Made offers a lifetime warranty.
Smith and Wesson only offers an ambidextrous cylinder release, which means the button is on both sides. The cylinder still releases to the left.