Hi,
I never use moonclips when plinking at the range with my powderpuff 200gn. LSWC bullets loaded with 5.3 gns. of Unique. The spent cartridges pull right out easily with fingernails. No sweat.
For full power SD ammo, you'll want moonclips mainly to speed reloading.
Thus you can shoot ammo three ways with your .45ACP Smith revolvers:
1. Without moonclips for casual shooting (though some later guns don't always fire reliably)
2. Using moonclips with .45ACP ammo
3. Using .45 Auto Rim ammo, loaded just like other rimmed revolver cartridges.
(NOTE: The Auto Rim cartridge is basically a .45ACP cartridge that is constructed at it's base just like any normal revolver cartridge with a rim to allow extraction using the ejector.)
Also, some hand loaders load .45AR cartridges hotter, due to the AR cartridges having more reinforcement in the back.
Here's a photo I made up that explains the Auto Rim cartridge to new (to .45ACP revolvers) folks.
Enjoy your wonderfully fun-to-shoot revolver!
Here's my favorite wheelgun of all time, a 6" barreled M25-2 that was chopped to 3 1/4" back "in the day" before S&W made this incredible revolver in shorter sizes for self defense. Incredible gun!