Hi,
They are both pretty similar, in recoil, accuracy, self-defense potential and in shooting fun. However . . . LOTS more ammo choices at decent prices for the .45ACP version, and lots more great defensive loads have been developed for the .45ACP too.
My vote is for the fast-reloading/moonclipped .45ACP version!
Here's mine . . . which was actually chopped to 3 1/4" back in the 1980s, long before S&W would give us a 25-2 with less than a six inch snout. It kind of looks like the modern LH Model 25 you are considering. Gorgeous lines and proportions!!!
IMHO, the Patrick Grashorn Elk Stags (from our own forum member and grip maker extraordinare) REALLY make the gun look great too!
Frankly, my chopped 25-2 is my favorite handgun of all time . . . and the very last I'd ever sell (although collectors would frown on a chopped barrel gun). Heck, I don't care . . . for nothing shoots as well in my hands.
Yep, I vote for the .45ACP version! You'll really enjoy it I'm sure!
Tom
PS: Welcome to the forum but . . . WARNING . . . this place gets addictive, and getting addicted to Smith wheelguns is both expensive AND so much fun!!!