There should be no misfires with your 327, regardless of ammo (provided it's quality factory) and whether or not you use the moon clips.
I'd say you might have gotten a bad batch of ammo, but if the problem on presents when not using the moon clips, this sounds like a revolver issue. Were the primers on the misfire ammo very slightly dented?
Have a look at your strain screw, located at the bottom of the front strap of the the frame, under the grips, and make sure it's properly tightened; do this carefully and with a properly sized screwdriver (if you're not comfortable doing this or confident that you can without damaging the strain screw, hold off). The strain screw tensions the mainspring, which drives the hammer -- if it's not adequately seated, you can get light strikes.
By the way, just in case you weren't aware, when you get a misfire, keep the barrel pointed down range in a safe direction and wait about 30 seconds. There's a phenomena called "hang fire" whereby the ignited primer has a slow burn that can seem like a misfire but things are just taking a while and that bullet's indeed a'comin'; rare, but a possibility to be aware of -- stay safe.
If the misfires aren't from a strain screw needing to be tightened, there's a host of other possibilities ranging from a too short firing pin to a weak mainspring to improper machining of the moon clip cuts on the cylinder to excess headspace and more. Not worth your time trying to personally determine.
Assuming you bought the 327 new, call S&W and arrange a trip to the mother ship for repair -- it should be a warranty fix on their dime assuming you haven't modified the revolver yourself in such a way that it might be causing the misfires.
If you bought the 327 used, contact the seller to determine if they know about any modifications that might be causing the problem and how to correct them. Also consider discussing a refund for a revolver not operating as intended.
However, if purchased used and you like it otherwise and want to keep it, contact S&W anyway and just let them know you have a 327 that isn't functioning properly -- they might do you a favor and fix it gratis even if you aren't the original purchaser.
Too, you can take it to a local S&W trained armorer or qualified gunsmith; if it's a simple problem they can probably provide a simple solution at a fair price. However, a good revolversmith is a pearl of great price and getting rarer these days in my estimation; finding one is its own kind of difficult hunt. In this case, I'd opt for a factory solution.
Your 327 should have no misfires with quality ammunition regardless of moon clips or no -- one way or another S&W can make it right.
Welcome to the forum.
