Not sure exactly what you seek but I’ll add my opinions.
I own many 1-2-3rd Gens. Generally speaking and specifically very easy to show on each pistol that I own... the 1st Gens seem to have gotten the most attention to detail during assembly and the improvement in parts production made the 3rd Gens the smoothest with the least amount of fitting help.
That leaves the 2nd Gen pistols as the ones with the least enjoyable fit and feel. The double action trigger pull on 2nd Gens are long, scratchy, heavy, crunchy and rough. The single action pull is better than the DA but the least impressive of the three different generation pistols, in my experience. You can also feel the lack of fitment and craftsmanship in the 2nd Gen safety lever and how it feels when you move it. And the slide to frame fit isn’t inspiring. Not that it should feel like art, but it feels less fit and less close than a 1st Gen or a 3rd Gen.
The 3rd Gen pistols (speaking specifically to the frame, as you asked) have ergonomic improvements that I really notice and really enjoy over the 1/2nd Gens.
The fact that you lose the option for traditional screw-on grips is a detriment to the 3rd Gen pistols, I would think that most folks would agree. The best facet of the one-piece grip on the 3rd Gen is that it is very thin, which was exactly what S&W was trying to gain with that grip.
The MIM parts are even better than the forged parts, they are made to very close tolerances and that’s why the net result is a smoother trigger pull in both modes.
These opinions of mine are formed from... 39’s, 39-2’s, 59, 639’s, 559, 659, 469, 745’s, 3906’s, 3953, 5906’s, 915’s, 4006’s, 4506, 4566... maybe some I forgot...? Only listing to say that these characteristics were not specific to single examples, they very much stuck to generations.
Theory as to why this is this way? In my opinion, guns were made differently back in the days of the 1st Gens. The guys working at S&W weren’t simply laborers, they were craftsmen, because they needed to be.
I believe that the 2nd Gens and 3rd Gens came from an era were many of the folks were assemblers and the guns didn’t need a lot of human intervention. The difference in the 3rd Gens is that the parts are better and the tolerances are closer and the end result seems to be a better fitting, feeling pistol.
Just how I see it. None of these slows me from having a lot of fun with my 2nd Gens, especially my 659 and my 745’s.