With the track record the standard .45 ACP in 230 gr. configuration has complied over the last 100 or so years, I can't see a need for jacked up pressures and velocities in a defensive handgun. I have a full sized M&P 45 that has ate a lot of rounds, some of them +P, and its seems no worse for wear (other than the black anodized striker breaking at around 7500 rounds and a lot more striker drops during dry fire). While excessive use of a +P+ may or may not blow the gun up, there will no doubt be increased wear and tear, and likely some parts breakage at some point or another.
I probably wouldn't hesitate to use 9mm +P+ on a limited basis thru an M&P 9, as I have also shot a bunch of them thru a G17 and 19 with no ill effect. Nevertheless, last year, I saw a guy's ultra-compact, single stack, DAO semi auto manufactured by a reputable American company basically Kaboom with +P and +P+. Since it was brand new, it digested around 300-500 rounds of +P FMJ training and at least 100 rounds of +P+ duty ammo before the barrel split chamber to muzzle, blowing out the dust cover and bulging the slide. Because of that, I would recommend adhering to the manufacturer's warnings about higher pressure ammo for most handguns.
Besides, the M&P 45 is not only a pleasant and rewarding pistol to shoot with standard 45 ACP ammo, but it is also a very effective defensive weapon when the shooter does his/her part and places rounds where they are effective.