I use Clays for all my handgun target loads. Given the few shots one will fire during deer season, I use factory loads for that and have a load with a cast 240-grain SWC that shoots to the same 25 yard point of impact as my factory Hornady 240-grain JHP loads, so I don't have to shoot a lot of sighter shots before going hunting each year. And I use only my .44s for hunting, so the smaller calibers are target guns only or with shot loads in them when I scout for deer prior to archery season when the creepy crawlers might be around.
In the 38 Special, I use 2.3 grains of Clays under a 148-grain LHBWC; in the .357, I use 4.0 grains under a 158-grain LSWC; in the .44 Magnum, I use 5.0 grains under that 240-grain LSWC and in the .45ACP, 4.0 grains under a 185-grain LSWC. All burn very clean and deliver good accuracy.
Clays Universal looks on paper to be a good powder for loads like mine but I learned the hard way that it needs a lot of heat and pressure to burn completely. I even had unburned powder still in the cases when I tried it in my guns. AutoComp performs similarly to Universal - lots of unburned powder unless the heat is turned up but who wants to use hot loads to punch paper?
Ed
Oh, I forgot to say that I think the component crisis is easing as the two local shops I frequent have nice inventories of powder, primers, bullets and other reloading supplies. Some stuff is still scarce - some types of .22LR ammo, for instance.