I've always been an advocate of a good revolver for a bedside gun. Simple as a hammer to operate under stress and/or when 1/2 asleep. Pull the trigger and it goes BANG. Pull again it .... etc. No worries of mis feeds, engaged safeties, dropped mags, fouled slides, etc. IMHO, lock a S&W revolver ( with a good flashlight) in a bedside, quick access safe and your good to go.
That said, after 30 years of doing just that , I have to admit I recently changed the bedside gun to an M&P 45 for multiple reasons.
First, reliability (in my testing) has rivaled that of a revolver. My M&P 45 eats anything I throw into it and has never had a FTF or any other hicup. Next, my M&P 45 has no manual safety and will fire with the mag dropped. Again, simplicity at it's finest. Not a whole lot of controls to fumble. As with the revolver, it's basically "pull the trigger and it goes BANG". Additionally, the M&P's design brings a comforting 11 rounds of 45ACP to the table in a recoil absorbing , ergo friendly package. Last, but not least, I have mounted a LED light to the guns rail. I find it a HUGE benefit in not having one hand tied up holding a flashlight for those midnight "bump in the dark" checks. Both hands stay on the gun and the light stays where the gun is pointing. The darn thing makes me feel invincible
Personally, I wouldn't keep anything more complex to operate for this purpose. I like having the knowledge that my wife could work the bedside gun on her own if I were not home.
hth