I suppose you mean a few tenths of a grain, i.e., weight, in which case yes, it may vary a bit with variations in humidity, but, apart from convenience, most of the point of measuring charges volumetricaly rather than by weight is to eliminate just this variable. Once you've established your optimum charge volume, you can forget the slight environmentally caused differences in weight, and you won't be using any more or less actual powder. Or, or so I understand... If i'm mistaken about this, I'm sure others will be quick to point it out.